IN VITRO AND IN VIVO SCREENING OF ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC AND AQUEOUS EXTRACTS OF ANOGEISSUS LATIFOLIA LEAVES

Objective: To evaluate and compare anti-oxidant anti-inflammatory activity of methanolic aqueous extract Anogeissus latifolia leaves Methods: The in vitro antioxidant was investigated using nitric oxide radical inhibition assay, hydroxyl scavenging DPPH free reducing power assay. erythrocyte membrane stabilization, protein denaturation, proteinase inhibitory the vivo carrageenan-induced rat paw edema. biochemical parameters were evaluated blood, which included determination serum glutamic oxaloacetic transaminase pyruvic values liver, includes estimation lipid peroxidation, reduced glutathione, superoxide dismutase. Results: caused a significant dose depended on reduction inflammation when compared with latifolia. all groups found to be comparable standard indomethacin group. maximum percent edema Anogeisuss at 500 mg/kg 53.33%, p<0.001. Conclusion: leaf possesses activity. therapeutic effect extracts will encourage its use treatment inflammation.